Lindane Topical: Uses, Side Effects, Interactions.
Lindane definition is - a persistent organochlorine insecticide that consists chiefly of the gamma isomer of BHC.
Table 1: The superlist classification code of Lindane. Lindane is widely used as an insecticide and as a therapeutic scabicide, pediculicide, and ectoparasiticide for humans and animals (Budavari et al., 1989). As an insecticide, it is used on fruit and vegetable crops including greenhouse vegetables and tobacco, for seed treatment, in forestry and for animal treatment. Registered uses also.
Lindane was toxic to the kidney and liver after administration orally, dermally or by inhalation in short-term and long-term studies of toxicity and reproductive toxicity in rats. The renal toxicity of Lindane was specific to male rats and was considered not to be relevant to human risk assessment, since it is a consequence of accumulation of a2u-globulin, a protein that is not found in humans.
Lindane is used as an insecticide on fruit and vegetable crops (including greenhouse vegetables and tobacco), for seed treatment and in forestry. It is also used as a therapeutic pesticide (e.g., in the treatment of scabies) in humans and animals (ATSDR, 1989; IPCS, 1991). Several countries have restricted the use of lindane. 1.5 Environmental fate In soil, lindane can be degraded under.
See related lindane information CIMS Abbreviation Index MIMS Abbreviation Index: Indications: Listed in Dosage. Dosage: Adult: Topical Scabies As 1% preparation: Apply on all skin areas from the neck to toes. Wash off after 8-12 hr. Pediculosis As 1% shampoo: Apply 30-60 mL to dry hair. Max: 60 mL. Massage into hair for 4 mins, then rinse thoroughly.
Lindane is the gamma isomer of hexachlorocyclohexane and is commonly referred to by the misnomer hexachlorobenzene. Technical-grade lindane contains 99 percent gamma-hexachlorocyclohexane, but also contains 1 percent of other isomers. Lindane is stable in the presence of light, heat, air, carbon dioxide, and strong acids; however, it is dehalogenated in the presence of alkali.
Lindane likely crosses and is stored in the human placenta. It is a known neurotoxin. One report describes a suicide attempt with oral ingestion at 16 w followed immediately by fetal death and vaginal bleeding. Fortunately, the maternal systemic concentrations after topical application (cream or shampoo) are low. An increased prevalence of IUGR has been suggested. Transfer across the rabbit.